Goleadores 2021
| Nombre | Apellido | Club | Uno | Dos | Tres | Cuatro | Cinco | Seis | Siete | Ocho | Nueve | Diez | Once | Liguilla Uno | Liguilla Dos | Liguilla Tres | Liguilla Cuatro | Total |
| Gustavo | Bortoli | (Deportivo Colonia) | | | | 1 | | 2 | 1 | | | | 3 | | | | | 7 |
| Christian | Franco | (Canadian) | | | | 1 | 1 | | | 1 | 1 | 1 | 1 | | | | | 6 |
| Martín | Mederos | (Parque del Plata) | | | 1 | | | | 2 | | 1 | 1 | 1 | | | | | 6 |
| Emanuel | Cuelllo | (Miramar Misiones) | | | 1 | | | 1 | | | 1 | 1 | | | 1 | | | 5 |
| Ignacio | San Martín | (Miramar Misiones) | | | 1 | 2 | | | | | | | | 2 | | | | 5 |
| Brian | Vargas | (Miramar Misiones) | | | | | 3 | | | | 1 | 1 | | | | | | 5 |
| Gino | Aguirre | (Canadian) | | | 3 | | | | | | | | 1 | | | | | 4 |
| Gastón | Álvarez | (Artigas) | | | | | 1 | 1 | 1 | | | 1 | | | | | | 4 |
| Dario | Giovanoni | (Salto) | | 1 | 1 | | 1 | | 1 | | | | | | | | | 4 |
| Douglas | Jardel | (Tacuarembó) | | 1 | 1 | | 1 | | | | | | 1 | | | | | 4 |
| Lucas | Martínez | (Colón) | | | | 1 | | 2 | | 1 | | | | | | | | 4 |
| Federico | Mautone | (Basáñez) | | | | | 1 | | 2 | | | | | 1 | | | | 4 |
| Guillermo | Méndez | (La Luz) | | | | | | | 2 | | 1 | | 1 | | | | | 4 |
| Diego | Sánchez | (Colón) | | | | | | 1 | | 1 | 1 | 1 | | | | | | 4 |
| Yoel | Burgueño | (Bella Vista) | | 1 | 1 | | 1 | | | | | | | | | | | 3 |
| Lucas | Di Fortuna | (Colón) | 1 | | | | 1 | | | 1 | | | | | | | | 3 |
| Emiliano | Fernández | (Platense) | | | | | | 1 | | | | 1 | 1 | | | | | 3 |
| Rodrigo | Hernández | (Huracán Buceo) | 1 | | | 1 | 1 | | | | | | | | | | | 3 |
| Pablo | Lemos | (Bella Vista) | 1 | | | 1 | | | | | | | | 1 | | | | 3 |
| Bruno | Motta | (Salus) | | 1 | | | | | 1 | | 1 | | | | | | | 3 |
| Lucas | Pazos | (Paysandú) | | | 2 | | | | | 1 | | | | | | | | 3 |
| Fernando | Penas | (Mar de Fondo) | | | 2 | | | 1 | | | | | | | | | | 3 |
| Anderson | Pérez | (Tacuarembó) | | | | 1 | 1 | | | | | | | 1 | | | | 3 |
| Christian | Silva | (Huracán) | 1 | 1 | | | | | 1 | | | | | | | | | 3 |
| Héctor | Acuña | (Miramar Misiones) | | | | 1 | | | | | | | | 1 | | | | 2 |
| Ronald | Álvarez | (Basáñez) | | | | | 1 | 1 | | | | | | | | | | 2 |
| Diego | Babón | (Salus) | | 1 | | | 1 | | | | | | | | | | | 2 |
| Marcio | Benítez | (Paysandú) | | 1 | | 1 | | | | | | | | | | | | 2 |
| Matías | Bentín | (Salto) | | | 2 | | | | | | | | | | | | | 2 |
| Sebastián | Burgos | (La Luz) | | | | | | | | | | | 1 | | 1 | | | 2 |
| Luis Fernando | Caicedo | (Colón) | | 1 | | 1 | | | | | | | | | | | | 2 |
| Andy | Calvo | (Alto Perú) | 1 | | | | | | | | 1 | | | | | | | 2 |
| Gerónimo | D’Olivera | (Oriental) | | | 2 | | | | | | | | | | | | | 2 |
| Federico | Estrella | (Salto) | | 1 | 1 | | | | | | | | | | | | | 2 |
| Agustín | Gallego | (Platense) | 1 | 1 | | | | | | | | | | | | | | 2 |
| Maximiliano | Giménez | (Canadian) | | | 1 | | | | | | 1 | | | | | | | 2 |
| Francisco | Gordillo | (Salus) | | | 1 | | | | | | | | | 1 | | | | 2 |
| Julián | Gottesman | (Bella Vista) | | 1 | | | | | | | | | | 1 | | | | 2 |
| Washington | Lencina | (Salus) | 1 | | | | | 1 | | | | | | | | | | 2 |
| Fernando | Lima | (Tacuarembó) | | | | 1 | 1 | | | | | | | | | | | 2 |
| Robert | Machado | (Potencia) | 1 | | | | | | 1 | | | | | | | | | 2 |
| Kenneth | Marascalchi | (Basáñez) | | | | | | 1 | | | | | | 1 | | | | 2 |
| Cristian | Martínez | (Parque del Plata) | | | | | | | 1 | | 1 | | | | | | | 2 |
| Diego | Martiñones | (La Luz) | | | | | | | | | | | 1 | 1 | | | | 2 |
| Michel | Miranda | (Potencia) | | | 1 | | | | 1 | | | | | | | | | 2 |
| Yefferson | Moreira | (Miramar Misiones) | | | | | 1 | | | | | | | | 1 | | | 2 |
| Fernando | Olivera | (La Luz) | 1 | | | | | | | 1 | | | | | | | | 2 |
| Alan | Olivera | (Mar de Fondo) | 1 | | 1 | | | | | | | | | | | | | 2 |
| Elias | Oyola | (Basáñez) | | | | | 2 | | | | | | | | | | | 2 |
| Agustín | Pereira | (Colón) | | | | | | 1 | 1 | | | | | | | | | 2 |
| Gonzalo | Pereira | (Miramar Misiones) | | | | 2 | | | | | | | | | | | | 2 |
| Federico | Pereira | (Salto) | | 1 | | 1 | | | | | | | | | | | | 2 |
| Facundo | Pérez | (Huracán Buceo) | | | | | | 1 | | 1 | | | | | | | | 2 |
| Facundo | Piazzze | (Oriental) | 1 | | | | | | 1 | | | | | | | | | 2 |
| Gonzalo | Pintos | (Colón) | | | | | | | | | 1 | 1 | | | | | | 2 |
| Esteban | Rodríguez | (Deportivo Colonia) | 1 | | | | | | | | | | 1 | | | | | 2 |
| Pedro | Rodríguez | (Tacuarembó) | | | 1 | | | | 1 | | | | | | | | | 2 |
| Diego | Rodríguez | (Tacuarembó) | | | | | | | | 1 | | | 1 | | | | | 2 |
| Sebastián | Sánchez | (Tacuarembó) | | | 1 | 1 | | | | | | | | | | | | 2 |
| Matías | Sarraute | (Huracán) | 1 | | | 1 | | | | | | | | | | | | 2 |
| Alejandro | Siles | (La Luz) | | | 1 | | | | | 1 | | | | | | | | 2 |
| Iván | Silva | (Tacuarembó) | | | | | | | | 1 | | | | 1 | | | | 2 |
| Lucas | Viana | (Tacuarembó) | | | | | | | 1 | 1 | | | | | | | | 2 |
| Ezequiel | Albín | (Salto) | | | | 1 | | | | | | | | | | | | 1 |
| Danilo | Alemán | (Huracán Buceo) | | | | | | | | | 1 | | | | | | | 1 |
| Guillermo | Álvarez | (Deportivo Colonia) | | | | | | | | | | 1 | | | | | | 1 |
| Anthony | Álvarez | (Miramar Misiones) | | | | 1 | | | | | | | | | | | | 1 |
| Christian | Anderson | (Los Halcones) | | | | | | | 1 | | | | | | | | | 1 |
| Federico | Andrade | (Bella Vista) | 1 | | | | | | | | | | | | | | | 1 |
| Wiminton | Araújo | (Artigas) | | | | | 1 | | | | | | | | | | | 1 |
| Agustín | Araújo | (Huracán) | | | | | | | | 1 | | | | | | | | 1 |
| Bruno | Ávila | (La Luz) | 1 | | | | | | | | | | | | | | | 1 |
| Andrés | Ayala | (Canadian) | | | | | | 1 | | | | | | | | | | 1 |
| Nahuel | Bardesio | (Artigas) | | | | | 1 | | | | | | | | | | | 1 |
| Brandon | Barrera | (Huracán Buceo) | | | | | | | | | 1 | | | | | | | 1 |
| Walter | Barreto | (Los Halcones) | | | | | | | 1 | | | | | | | | | 1 |
| Juan | Barrios | (Parque del Plata) | | | | | | | | | | 1 | | | | | | 1 |
| Changa | Bass | (Huracán Buceo) | | | | | | 1 | | | | | | | | | | 1 |
| Oscar | Bassadone | (Paysandú) | | 1 | | | | | | | | | | | | | | 1 |
| Armando | Benítez | (Tacuarembó) | | | | | | 1 | | | | | | | | | | 1 |
| Lazaro | Branca | (Paysandú) | | 1 | | | | | | | | | | | | | | 1 |
| Maximiliano | Caetano | (La Luz) | | 1 | | | | | | | | | | | | | | 1 |
| Bruno | Camargo | (Salto) | | | | 1 | | | | | | | | | | | | 1 |
| Santiago | Caraballo | (Platense) | 1 | | | | | | | | | | | | | | | 1 |
| Brandon | Cardozo | (Bella Vista) | 1 | | | | | | | | | | | | | | | 1 |
| Brian | Cardozo | (Platense) | | | | | | | | | | | 1 | | | | | 1 |
| Jhon | Casavieja | (Alto Perú) | | | | | | | | 1 | | | | | | | | 1 |
| Lucas | Casavieja | (Bella Vista) | | | | | | | | 1 | | | | | | | | 1 |
| Oscar | Castro | (La Luz) | | 1 | | | | | | | | | | | | | | 1 |
| Jonathan | Charquero | (Basáñez) | | 1 | | | | | | | | | | | | | | 1 |
| Diego | Cordero | (Huracán) | | | | 1 | | | | | | | | | | | | 1 |
| Mario | Correa | (Platense) | | | | | | | 1 | | | | | | | | | 1 |
| Esteban | Correa | (Platense) | | | 1 | | | | | | | | | | | | | 1 |
| Andrés | Curbelo | (Oriental) | 1 | | | | | | | | | | | | | | | 1 |
| Matias | De Carlos | (Platense) | 1 | | | | | | | | | | | | | | | 1 |
| Nelson | Dos Santos | (Tacuarembó) | | | | | | | | | 1 | | | | | | | 1 |
| Alem | Durán | (Platense) | | | | | | | 1 | | | | | | | | | 1 |
| Lucas | Esmoris | (Canadian) | | | | | | | | | | 1 | | | | | | 1 |
| Agustín | Espel | (Mar de Fondo) | | 1 | | | | | | | | | | | | | | 1 |
| Franco | Fagundez | (Paysandú) | | 1 | | | | | | | | | | | | | | 1 |
| Franco | Farinasso | (Bella Vista) | | | | | | | | 1 | | | | | | | | 1 |
| Axel | Fernández | (Oriental) | | | | | 1 | | | | | | | | | | | 1 |
| Maximiliano | Ferreira | (Platense) | | | | 1 | | | | | | | | | | | | 1 |
| Denis | Ferreira | (Platense) | | | | | | 1 | | | | | | | | | | 1 |
| Emanuel | Fuentes | (La Luz) | | 1 | | | | | | | | | | | | | | 1 |
| Kevin | Gadea | (Salus) | | | 1 | | | | | | | | | | | | | 1 |
| Andrés | Garcia | (La Luz) | | | | | | | | 1 | | | | | | | | 1 |
| Facundo | García | (Parque del Plata) | | | | | | | | | | 1 | | | | | | 1 |
| Lucas | Geymonat | (Deportivo Colonia) | | | | | | | 1 | | | | | | | | | 1 |
| Daniel | Golarte | (Artigas) | | | | | | | | | 1 | | | | | | | 1 |
| Nicolás | Gómez | (Miramar Misiones) | | | | 1 | | | | | | | | | | | | 1 |
| Jorge | González | (Basáñez) | | | | | | | | | 1 | | | | | | | 1 |
| Franco | González | (Paysandú) | | | | | | | 1 | | | | | | | | | 1 |
| Darwin | Graña | (Basáñez) | | | | | | | | 1 | | | | | | | | 1 |
| Christian | Heguaburo | (Oriental) | | | | | | | | | 1 | | | | | | | 1 |
| Leonardo | Herrera | (Deportivo Colonia) | 1 | | | | | | | | | | | | | | | 1 |
| Jonathan | Lúquez | (Paysandú) | | | | | 1 | | | | | | | | | | | 1 |
| Jorge | Malaquín | (Artigas) | | | | | | | | | | 1 | | | | | | 1 |
| Franco | Marfei | (Alto Perú) | | | | | | | 1 | | | | | | | | | 1 |
| Joel | Martínez | (Mar de Fondo) | | | | | | | | 1 | | | | | | | | 1 |
| Gonzalo | Martínez | (Potencia) | | | | | | | | | 1 | | | | | | | 1 |
| David | Medina | (Los Halcones) | | | | | | 1 | | | | | | | | | | 1 |
| Nicolás | Morales | (Salto) | | | | | | | 1 | | | | | | | | | 1 |
| Matias | Núñez | (Mar de Fondo) | | | | | | | | 1 | | | | | | | | 1 |
| Christian | Núñez | (Paysandú) | | 1 | | | | | | | | | | | | | | 1 |
| Maicol | Olivera | (Huracán) | | | | | | | | | 1 | | | | | | | 1 |
| Sandy | Olivera | (Platense) | | | | | | | 1 | | | | | | | | | 1 |
| Andrés | Pérez | (Basáñez) | | | | | | | | | 1 | | | | | | | 1 |
| Andrés | Pérez | (Miramar Misiones) | | 1 | | | | | | | | | | | | | | 1 |
| Fabian | Pesca | (Oriental) | | | | | | | | | | | 1 | | | | | 1 |
| Facundo | Piñeyro | (Artigas) | | | | | | | | | | 1 | | | | | | 1 |
| Nicolás | Ramírez | (Canadian) | | | | | | | | | | | 1 | | | | | 1 |
| Juan José | Rodríguez | (Bella Vista) | | | | | | | | | 1 | | | | | | | 1 |
| Christian | Rodríguez | (Tacuarembó) | | | | | | | | | | | 1 | | | | | 1 |
| Yahir | Ruíz | (Artigas) | | | | | 1 | | | | | | | | | | | 1 |
| Gastón | Sacco | (Los Halcones) | | | | | | | | 1 | | | | | | | | 1 |
| Itan | Salvarrey | (Salus) | 1 | | | | | | | | | | | | | | | 1 |
| Diego | Sierra | (Alto Perú) | | | | | | | 1 | | | | | | | | | 1 |
| Matías | Silvera | (Mar de Fondo) | | | | | 1 | | | | | | | | | | | 1 |
| Juan | Silvera | (Salto) | | | | | | | | | 1 | | | | | | | 1 |
| Luciano | Soria | (Deportivo Colonia) | | | | | | | | | | 1 | | | | | | 1 |
| Rodrigo | Sosa | (Huracán Buceo) | | | | | | | | | 1 | | | | | | | 1 |
| Lucas | Suárez | (Miramar Misiones) | 1 | | | | | | | | | | | | | | | 1 |
| Leandro | Sureda | (Potencia) | 1 | | | | | | | | | | | | | | | 1 |
| Lucas | Tamareo | (Miramar Misiones) | | | | | | | 1 | | | | | | | | | 1 |
| Jonathan | Techera | (Basáñez) | | | | | | | | | | | | 1 | | | | 1 |
| Sebastián | Tregarthen | (Huracán Buceo) | | | | | | | 1 | | | | | | | | | 1 |
| Luciano | Urán | (Oriental) | 1 | | | | | | | | | | | | | | | 1 |
| Christian | Vaquero | (Basáñez) | | | | | | 1 | | | | | | | | | | 1 |
| Bruno | Varela | (Potencia) | | 1 | | | | | | | | | | | | | | 1 |
| Lucas | Vignone | (Huracán) | 1 | | | | | | | | | | | | | | | 1 |
| Facundo | Vignone | (Oriental) | | | 1 | | | | | | | | | | | | | 1 |
| Mateo | Vila | (Parque del Plata) | | | | | | | 1 | | | | | | | | | 1 |
| Diego | Viña | (Miramar Misiones) | 1 | | | | | | | | | | | | | | | 1 |
| Maximiliano | Arias | (Platense) | | | | | | e/c | | | | | | | | | | 0 |
| Lucas | Bonini | (Canadian) | | | | | | | | | | (e/c) | | | | | | 0 |
| Francisco | Collares | (Paysandú) | | | | | | | | | | | | | | | | 0 |
| Facundo | Garcia | (Artigas) | | e/c | | | | | | | | | | | | | | 0 |
| Mauricio | Garrido | (Potencia) | | | | | | | | e/c | | | | | | | | 0 |
| Martín | Lencina | (Potencia) | | | | | | | | e/c | | | | | | | | 0 |
| Santiago | Mesa | (Huracán) | | | | | | | | (e/c) | | | | | | | | 0 |
| Nicolás | Reyes | (Huracán Buceo) | | | | | | e/c | | | | | | | | | | 0 |
